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Viramune

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Viramune is a powerful anti-HIV drug that is used as a part of active anti-retroviral therapy. The medication can be used in adults only with weight 50 kg and more. Viramune treats HIV-1 infection but doesn't cure it. Read more

Other names for this medication:
Nevimune®

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Active Ingredient:
Nevirapine

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Description

Viramune's active ingredient is Nevirapine – a non-nuke or NNRTI (non-nucleoside reverse transcriptase inhibitor).

Indications:

- treatment and control of the HIV type 1 infection, as part highly active anti-retroviral therapy (HAART).

MOA (mechanism of action):

Nevirapine interferes with reverse transcriptase (RT) – an enzyme used by HIV-infected cells to make new copies of virus. Since Nevirapine blocks, or reduces the activity of the RT, the HIV viral load is significantly decreased. Therefore, Nevirapine helps control infection, reduces the risk of opportunistic infections and AIDS. Nevirapine isn't active against HIV-2.

Dosage

The recommended dose is 200 mg per day for the first 14 days of treatment ("lead-in" period). After 14 days, the usual dose is 200 mg twice a day.

It is very important that you take only one 200 mg Viramune tablet a day for the first 14 days. If you have developed rash during this period, do not increase the dose but consult your doctor.

The 14-day "lead-in" period has been shown to lower the risk of skin rash.

As Viramune must always be taken together with other HIV anti-retroviral drugs, you should follow the instructions for the other medications carefully.

Precautions:

During the first 18 weeks of taking Viramune watch out for symptoms of liver or skin reactions (e.g., fever, blistering, mouth sores, inflammation of the eye, swelling of the face, general swelling, shortness of breath, muscle or joint pain, general feelings of illness, abdominal pain). These can become severe and even life-threatening. Patient is at greatest risk of such reaction in the period of the first 6 weeks.

Additional symptoms to look for include ulcers in the mouth, throat, nose, genitals, and conjunctivitis.

These potentially life-threatening skin reactions often appear with flu-like symptoms. The rash may progress to widespread blistering or exfoliating of the skin.

If while using Viramune you have developed Stevens-Johnson syndrome or toxic epidermal necrolysis, you must not be restarted on Viramune at any time.

If you develop a rash or aforementioned skin symptoms, seek immediate medical advice and tell about taking Viramune.

Stop taking Viramune immediately if you experience symptoms of the liver damage (loss of appetite, nausea, vomiting, yellow skin (jaundice), abdominal pain).

If while using Viramune you have developed severe liver, skin or allergic reactions, never take Viramune until your doctor tells you to do so.

The following individuals are at increased risk of developing liver problems: women, infected with hepatitis B or C, those with abnormal liver function tests, treatment-naive patients with higher CD4 cell count at the beginning of Viramune therapy (women more than 250 cells/mm3, men more than 400 cells/mm3), pre-treated patients with detectable HIV-1 plasma viral load and higher CD4 cell count at the beginning of Viramune therapy (women more than 250 cells/mm3, men more than 400 cells/mm3).

HIV can be transmitted through sexual contact with HIV positive partner, blood (e.g., sharing needles, handling blood instruments, receiving blood transfusions, blood products, or organ/tissue transplants that were infected with HIV), childbirth, toiletries (razors and toothbrushes). Therefore, both HIV-positive and HIV-negative individuals are advised to have any kind of sex using a latex or polyurethane condom, avoid sharing needles or other things like toothbrushes or razors. It is important to discuss with doctor the precautions needed to avoid infecting other people as well as take precautions not to get infected.

Women who are HIV-positive must not breastfeed because HIV infection can be passed on to the baby in breast milk.

Some people who take Viramune may experience:

- Symptoms of inflammation from previous infections.

- Autoimmune reactions (conditions that occur when the immune system attacks healthy body tissue).

- Changes in body fat.

- A bone disease called osteonecrosis (death of bone tissue caused by loss of blood supply to the bone).

Missing a dose

If you miss a dose you should take it as soon as you remember about your missing. If it is the time for the next dose you should continue your regular dosing schedule. Do not take a double dose of Viramune to compensate the missed dose.

Overdose

If an overdose occurs and you are not feeling well, stop taking the medication immediately. You should seek emergency medical attention or contact your healthcare provider immediately.

Storage

Store Viramune tablets or oral powder at room temperature between 68-77 degrees F (20-25 degrees C). Keep Viramune in the original container. Do not use Viramune if the seal over the bottle opening is broken or missing. Keep the bottle tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

Common side effects associated with Viramune are:

  • decreased numbers of white blood cells (granulocytopenia)
  • allergic reactions
  • headache
  • nausea
  • vomiting
  • abdominal pain
  • diarrhea
  • hepatitis
  • fatigue
  • fever
  • abnormal liver function tests

Side effects occurrence does not only depend on the medication you are taking, but also on your overall health and other factors.

Contraindications

Viramune is contraindicated in patients who are allergic to Nevirapine or any of the other ingredients of Nevimune®.

Do not take Viramune if you suffered from severe skin rash, skin rash with other symptoms (fever, blistering, mouth sores, inflammation of the eye, swelling of the face, general swelling, shortness of breath, muscle or joint pain, general feelings of illness, abdominal pain), allergic reactions, liver problems (hepatitis).

Do not combine Viramune with such medications as St John’s Wort, tuberculosis drugs (rifampicin, rifabutin, macrolides (clarithromycin to treat bacterial infections), antifungals (fluconazole, ketoconazole, itraconazole, itraconazole), methadone (drug used for treatment of opiate addicts), anticoagulants (warfarin), hormonal contraceptives, another HIV drugs as you may not know the right combination regimen (e.g., atazanavir, lopinavir/ritonavir, fosamprenavir, efavirenz, etravirine, rilpivirine, delavirdine, zidovudine, boceprevir, telaprevir, elvitegravir/cobicistat).

Do not take Prednisone to treat a rash associated with taking Viramune.

Do not take Viramune if you have severe liver disease or if you have had to stop Nevirapine treatment in the past because of changes in your liver function.

Do not take Viramune if you are taking a medicine containing the herbal substance St John’s Wort. This herbal substance may interfere with Nevirapine's effectiveness.

Do not have any kind of sex without using a latex or polyurethane condom.

Do not share needles or other things like toothbrushes or razors.

Do not take Viramune if you are pregnant or plan to have a baby. First, consult your healthcare provider.

Women who are HIV-positive must not breastfeed because HIV infection can be passed on to the baby in breast milk.

Q: What is Viramune used for?

A: Viramune is a powerful anti-HIV drug that is used as a part of active anti-retroviral therapy. The medication can be used in adults only with weight 50 kg and more. Viramune treats HIV-1 infection but doesn't cure it.

Q: Can I have sex when taking Viramune?

A: You should know neither Viramune nor any other anti-retroviral medication can cure HIV. It is therefore important that you have safe sex and take other precautions to avoid passing HIV on to other people. Do not have any kind of sex without using a latex or polyurethane condom.

Q: Can I breastfeed if I take Viramune?

A: Women who are HIV-positive must not breastfeed because HIV infection can be passed on to the baby in breast milk.

Target Point Shipping Method Tracking Delivery Time Price
Worldwide Shipping

Worldwide Shipping

Registered Mail  Not trackable 14-21 business days USD 15.00 per order
EMS  Trackable, where available 5-9 business days USD 25.00 per order

Delivery time is:

Registered Mail - 14-21 business days, price - USD 15.00, no signature is required on delivery.
EMS - 5-9 business days, price - USD 25.00, signature is required on delivery.
Your order will be packed safe and secure and dispatched within 24 hours.

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